Non-parametric optimal design in dose finding studies
نویسندگان
چکیده
منابع مشابه
Optimal designs for dose finding studies
Identifying the “right” dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated safety problems, while choosing too low a dose leads to smaller chances of showing sufficient efficacy in confirmatory trials, thus reducing the c...
متن کاملwww.econstor.eu Optimal designs for dose finding studies
Identifying the “right” dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated safety problems, while choosing too low a dose leads to smaller chances of showing sufficient efficacy in confirmatory trials, thus reducing the c...
متن کاملPractical considerations for optimal designs in clinical dose finding studies.
A key objective in the clinical development of a medicinal drug is the determination of an adequate dose level and, more broadly, the characterization of its dose response relationship. If the dose is set too high, safety and tolerability problems are likely to result, while selecting too low a dose makes it difficult to establish adequate efficacy in the confirmatory phase, possibly leading to...
متن کاملwww.econstor.eu Optimal designs for dose finding experiments in toxicity studies
We construct optimal designs for estimating fetal malformation rate, prenatal death rate and an overall toxicity index in a toxicology study under a broad range of model assumptions. We use Weibull distributions to model these rates and assume that the number of implants depend on the dose level. We study properties of the optimal designs when the intra-litter correlation coefficient depends on...
متن کاملOptimal designs for dose-finding experiments in toxicity studies
We construct optimal designs for estimating fetal malformation rate, prenatal death rate and an overall toxicity index in a toxicology study under a broad range of model assumptions. We use Weibull distributions to model these rates and assume that the number of implants depend on the dose level. We study properties of the optimal designs when the intra-litter correlation coefficient depends on...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2002
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/3.1.51